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Ghati-Pal is Indian unit of time. In other words, from English clock, we know timeby Hour - Minute - Second, similarly Hindu clock comprises Ghati - Pal - Vipal.And, a day is of 24 hour and 60 Ghati. Like a general day starts from mid-night,that is, 12 o'clock; Hindu day starts with sunrise. So, first Ghati begins withthe time of sunrise, as first hour begins after 12 o'clock. The combination of hour- minute - second is known as time. Time given in Ghati - Pal - Vipal is called'Ishta-kaal'. AstroSage has offered Ghati to Hour convertor for the ones who havetheir Kundalis made as per the format of Ishtakaal. In this modern world, it isvery difficult to make astrological predictions on the basis of Ishtakaal. So, AstroSage's'Ghati to Hour convertor' will assist you to find your birth time as per your convenience.There is another aspect for finding time of your Ishtakaal; it is that you shouldknow the exact time of sunrise for that day. No, this tool is not paid. It is availablehere for FREE! Just scroll down, fill your details, press enter and your time willbe here.
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Ghati to Hour conversion is important because even today's astrologers are experiencedin making Kundalis from English clock. Ghati is also known as Ghatika in North Indiaand Nizhika in South India. Some of you might already have your birth chart in thetime format and must be wondering about your Ghati. So, you may find your Ghatiby making Free Kundali at AstroSage. In your Kundali, there will be a corner foryour birth details; it will be having your Ishtakaal. AstroSage is the only placethat offers you 100% genuine Ghati to Hour convertor. This convertor is tested properlybefore publishing for our readers online. So, don't hesitate to find your time fromIshtakaal. All you need in this context is your Ishtakaal and sunrise time of thatparticular day. If this convertor couldn't come in much use of you then it musthave at least taught you much about our Indian time or say Hindu time or Ishtakaal.Anyways, you shouldn't miss more time and utilize this FREE of cost tool. It wouldbe great if you could help your closed ones by sharing this tool with them.
For older patients with cancers of other sites, site-specific life expectancy nomograms and guidelines are comparatively lacking. In this circumstance, the clinician must empirically weigh the anticipated timeframe, trajectory, and tempo of risks for noncancer mortality, noncancer morbidity (disease, symptoms, and impact on health and function), cancer mortality, cancer morbidity, and treatment morbidity. Weighing these competing risks contextualizes a patient's cancer treatment priorities holistically within his or her entire spectrum and time course of health needs. In certain disease sites (eg, lymphoma and early-stage endometrial cancer), adjuvant radiation therapy is found to benefit event-free survival but not necessarily overall survival. In this circumstance, a competing-risk assessment remains relevant, but it should be modified. Here, the clinician should emphasize the impact of radiation treatment on the timeframe and trajectory of the event-free survival curve as opposed to overall survival curve, also balanced against noncancer mortality and morbidity risks over time.
In astrology, an aspect is an angle that planets make to each other in the Horoscope; as well as to the Ascendant, Midheaven, Descendant, Lower Midheaven, and other points of astrological interest. As viewed from Earth, aspects are measured by the angular distance in degrees and minutes of ecliptic longitude between two points. According to astrological tradition, they indicate the timing of transitions and developmental changes in the lives of people and affairs relative to the Earth.
For example, if an astrologer creates a Horoscope that shows the apparent positions of the celestial bodies at the time of a person's birth (Natal Chart), and the angular distance between Mars and Venus is 92 ecliptic longitude, the chart is said to have the aspect "Venus Square Mars" with an orb of 2 (i.e., it is 2 away from being an exact Square; a Square being a 90 aspect). The more exact an aspect, the stronger or more dominant it is said to be in shaping character or manifesting change.
In medieval astrology, certain aspects and planets were considered to be either favorable (benefic) or unfavorable (malefic). Modern usage places less emphasis on these fatalistic distinctions. The more modern approach to astrological aspects is exemplified by research on astrological harmonics. In 1619, Johannes Kepler advocates this in his book Harmonice Mundi. Thereafter, John Addey was a major proponent. However, even in modern times, aspects are considered to be either easy (60 Sextile or120 Trine) or hard (90 Square or 180 Opposition). Depending on the involved planets, a Conjunction (0, which is a discounting orb) may be in either category.
When calculating or using aspects, it is important to note that different astrologers and separate astrological systems/traditions utilize differing orbs, which is the degree of separation between exactitude. Orbs may also be subject to variation, depending on the need for detail and personal preferences. Although, when compared to other aspects, almost all astrologers use a larger orb for a Conjunction.
Collective astrological data along with Johannes Kepler described 13 aspects in his book Harmonice Mundi. Astrological data grouped together in five degrees of influentially picked from symbol ratios encountered in geometry and music: 0/2, 1/2, 1/5, 2/6, 1/3, 1/12 along with 1/5, 2/5, 15/5, 10, 10/3, 8, and 8/3. The general names for whole divisors are (Latin) n-ile for whole fractions 1/n, and m-n-ile for fraction m/n. A Semi-n-tile is a 2n-tile, 1/(2n), and Sesqui-n-tile is a Tri-2n-tile, 3/(2n).
In the past, Great Conjunctions between the two slowest classical planets, Jupiter and Saturn, have attracted considerable attention as celestial omens. This interest can be traced back to Arabic translations found in Europe; most notably Albumasar's book on Conjunctions. During the late Middle Ages and the Renaissance, these omens were a topic broached by most astronomers. This included scholastic thinkers, such as Roger Bacon and Pierre D'Ailly. Omens are also mentioned in popular literary writings by authors, such as Dante and Shakespeare. This interest continued up to the times of Tycho Brahe and Kepler.
To each triangular pattern, astrologers have ascribed one from a series of four elements. Particular importance has been accorded to the occurrence of a Great Conjunction in a new Trigon, which is bound to happen after 240 years at most. Greater importance is attributed to the beginning of a new cycle, which may occur after all four Trigons have been visited, which occurs in 900 years.
Typically, medieval astrologers used 960 years as the length of the full cycle, because, in some cases, it took 240 years to pass from one trigon to the next. If a cycle is defined by when the Conjunctions return to the same right ascension rather than to the same constellation, the cycle is only 800 years, because of axial precession. Use of the Alphonsine tables apparently led to the use of precessing signs; Kepler gave a value of 794 years, which created 40 Conjunctions.
An Opposition is said to be the second most powerful aspect. It resembles a conjunction, but an Opposition is fundamentally relational and it is not unifying like a conjunction. Some astrologers say it is prone to exaggeration, because it has a dichotomous quality and an externalizing effect.
All important axes in astrology are essentially Oppositions. Therefore, at its most basic level, an Opposition may often signify a relationship that can be oppositional or complementary.
A Semioctile is part of the square family. It is considered to be a more minor version of the Semisquare, which triggers challenge. Its harmonic aspects are 45, 67.5, 90, 112.5, 135, 157.5 and 180. It was discovered by Uranian astrologers.
The Parallel and Contraparallel or Antiparallel are two other aspects which refer to degrees of declination above or below the Celestial Equator. They are not widely used by astrologers.
A Contraparallel may be similar to the Parallel. Some astrologers that use the Parallel do not consider the Contraparallel to be an aspect. An orb of the opposite degree 1 with a 12-minute arc is allowed.
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The estimated rate of a major cytogenetic response at 18 months was 87.1% in the imatinib group and 34.7% in the group given interferon alfa plus cytarabine. At 18 months, the estimated rate of freedom from progression to accelerated-phase or blast-crisis CML was 96.7% in the imatinib group and 91.5% in the combination-therapy group. Imatinib was better tolerated than combination therapy. 
Treatment of patients with CML in the accelerated phase or in blast crisis has yielded dismal results. Although imatinib can induce a hematologic response in 52-82% of patients, the response is sustained for at least 4 weeks in only 31-64% of patients. The complete response rate is lower, at 7-34% of patients. Karyotypic response occurs in 16-24%, and complete cytogenetic response is observed in only 17%.  Higher doses (ie, 600 mg/d) result in improved response rates, cytogenetic response, and disease-free and overall survival.
A study by Cortes et al that compared dasatinib 100 mg daily or 50 mg twice daily for at least 3 months as initial therapy for early chronic-phase CML found no difference in outcome between the 2 dosages.  Of the 50 patients in the study, 49 (98%) achieved a complete cytogenetic response and 41 (82%) achieved a major molecular response. The projected event-free survival rate at 24 months was 88%, and all patients were alive after a median follow-up time of 24 months.